What is Orlistat?
Orlistat is a medication that is used to help reduce weight in obesity. It also supports individuals to help maintain weight loss, by reducing the chance of putting weight back on. Orlistat is taken with meals and blocks around 30-40% of fat from being absorbed by your body, passing it out in your stools. It works best in conjunction with a reduced calorie diet and clinical trials have suggested that it can also have a beneficial effect on blood pressure and diabetes. It is licensed for use in adults only.
What is the difference between Orlistat and Alli and Xenical?
Orlistat is the active ingredient that is contained in Alli and Xenical. Alli and Xenical are branded versions of Orlistat. Orlistat is also available as a non-branded (generic) version, known as just Orlistat. So, there are three types:
- Non-branded (generic) Orlistat (contains 120mg of orlistat)
- Xenical (contains 120mg of orlistat)
- Alli (contains 60mg of orlistat)
Xenical and generic orlistat contain 120mg of orlistat and are only available on prescription. Alli contains 60mg of orlistat and is available to buy over the counter. The higher doses of orlistat present in Xenical and the generic version, means that weight loss is likely to be noticeable quicker, with noticeable results presenting after the first few weeks of treatment. Results with Alli may be slightly slower, however some people may decide they would like to start off with a lower strength before increasing.
In simple terms, all three versions are medically the same and contain the same active ingredient, orlistat. They only differ in strength and price.
How does Orlistat work?
Fat from our diet is broken down by enzymes and absorbed by our body. Excess fat consumed, means that more fat is broken down by enzymes and absorbed by our body. More fat absorbed means more fat is stored and the result is that we put on weight.
Orlistat works by blocking the enzymes in the stomach and intestines from breaking down fat, which means it cannot be absorbed by the body. The fat passes through the gut and is excreted in the faeces.
Is Orlistat safe?
Orlistat is a licensed product and is used by millions around the world. It has been reviewed and tested for its safety and effectiveness. There have been many drugs that have been tested to treat obesity, but orlistat is the only one that has proven to be both safe yet effective.
Is Orlistat effective?
A clinical trial conducted by doctors looked at the effectiveness of Orlistat over a 2-year period. The study looked at two groups of patients, one group that took orlistat and the other group that took a placebo (tablet that has no effect). The results showed that at the end of the first year, the group taking orlistat lost more weight than the group that took the placebo. During the second year, the participants followed a weight-maintenance diet and after the second year, the results showed that the group taking orlistat gained 50% less weight than those taking the placebo.
Another study looked at the weight, blood sugar levels and lipid (cholesterol) levels of 391 obese participants over a 57-week period. The results showed that those taking orlistat lost more weight and had a significant improvement in blood sugar and lipid levels than those taking the placebo.
Overall, there have been many studies looking at the effectiveness of orlistat in helping to reduce weight. Most studies conclude that orlistat is effective in helping to reduce weight.
Will I lose weight with Orlistat?
Orlistat has helped many people lose weight. Studies and research has shown that orlistat is clinically effective in helping to reduce weight in obese individuals. However, in order to maximise its effectiveness and experience beneficial results, it is important to take orlistat in conjunction with a calorie-reduced diet and an increase in exercise. This way, you are likely to see encouraging results and avoid disappointment. Just remember, results will not happen overnight and it is important to be persistent and stay positive.
When should you use Orlistat?
Orlistat is prescribed for obese or overweight individuals who have a Body Mass Index (BMI) of 30kg/m² or more, or those with a BMI of 28kg/m² who have other risk factors for obesity related diseases such as type 2 diabetes, high blood pressure or high cholesterol. It is only to be used for those aged 18 and above (in special circumstances, it may be prescribed for children over the age of 12 as an unlicensed use of the medication).
When should you stop using Orlistat?
If you have been using orlistat in conjunction with a calorie reduced diet for three months and have not experienced a reduction in weight, you should stop taking orlistat and seek medical advice. It may be the case that the strength needs to be increased (if you have been taking the lower 60mg strength), or it may be that your diet isn't as disciplined as it should be (many people have common misconceptions about what a good diet is). You may even need to start exercising more, but it is important to seek the opinion of a healthcare professional on what you should do next.
How do I take Orlistat?
- Take one capsule immediately before, during or up to one hour after your meals (breakfast, lunch and dinner)
- Swallow the capsule with water
- If a meal does not contain fat, you do not need to take a capsule
- Avoid snacks that contain fat in-between meals
Orlistat should be used in conjunction with an increase in exercise and a decrease in calories and fat. Your daily intake of fat should be no more than 30% of your daily calorie intake. For example, if your daily calorie intake is 1,800 calories, no more than 540 calories (30% of 1,800 calories) should come from fat. Most food packaging has nutritional information that can be used to help you.
Does Orlistat help control diabetes and high blood pressure?
Clinical trials have shown that orlistat has worked to improve high blood pressure, increased lipid levels and type 2 diabetes. It is unclear whether this is a direct result of orlistat, or the positive outcome of a reduction in weight.
Can you buy Orlistat over the counter?
Orlistat 60mg comes in a branded version known as Alli. It is possible to purchase Alli over the counter. The higher strength Xenical or generic orlistat, contain 120mg of orlistat and can only be obtained with a prescription.
Buy Orlistat Online
Orlistat is available to buy online from our registered pharmacy. Orlistat is the active ingredient also contained in the branded versions, Alli and Xenical. Because this is a non-branded product, you are able to buy Orlistat online for a cheaper price. Before our clinicians can prescribe this, you will need to fill out a short online questionnaire, which will determine your suitability for this product.