Although Wegovy starts working straight away, weight loss results are not visible till the second month.

How quickly it works depends on several factors, including your diet, activity level, metabolism, and how consistently you take it.

While some feel appetite changes early on, effectiveness usually builds over time, especially when Wegovy is combined with healthy lifestyle habits.

When does Wegovy start working?

Month 1

  • Dosage: 0.25mg once weekly (starter dose)
  • Effects: Appetite may begin to decrease; some reduced cravings. Remember, this is a sub-therapeutic dose, where Wegovy is slowly introduced before gradually building up the dose. This reduces the chances of side effects.
  • Expected Weight Loss: Minimal, your body is adjusting.
  • Key Takeaway: After the first month on Wegovy, you are likely to notice your appetite shrinking, however, you may not necessarily see any visible changes to your weight.

Month 2

  • Dosage: 0.5mg weekly
  • Effects: Noticeable weight loss; improved portion control.
  • Expected Weight Loss: Around 4% of starting weight.
  • Key Takeaway: After 2 months on Wegovy, you should start to notice a reduction in weight. The 0.5mg dose is when Wegovy starts working to help you lose weight.

Month 3

  • Dosage: 1mg
  • Effects: More steady, significant weight loss; better energy levels, mobility, sleep and overall mood.
  • Expected Weight Loss: Around 6% of starting weight.
  • Key Takeaway: After 3 months on Wegovy, you should start to see visible weight loss results.

Month 4

  • Dosage: 1.7mg weekly (maintenance/target dose)
  • Effects: More steady, significant weight loss; rising energy levels, improved confidence.
  • Expected Weight Loss: Around 8% of starting weight over time.
  • Key Takeaway: You should be continuing to lose weight at a steady level

Month 5

  • Dosage: 2.4mg weekly (maintenance/target dose)
  • Effects: Continued weight loss with energy increasing as treatment continues. Blood sugar levels, blood pressure and overall health should have improved considerably at this stage.
  • Expected Weight Loss: Up to 10% of starting weight
  • Key Takeaway: After 5 months on Wegovy, you should have lost up to 10% of your starting weight.

Month 6 onwards

  • Dosage: 2.4mg weekly (maintenance/target dose)
  • Effects: Overall improvement in health.
  • Expected Weight Loss: Up to 17% of starting weight.
  • Key Takeaway: After 6 months on Wegovy, you should be on your way to losing up to 17% of your starting weight (assuming you continue with treatment for 17 months).

*These results are based on the study Once-Weekly Semaglutide in Adults with Overweight or Obesity

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What can affect how quickly Wegovy works?

Several factors can speed up or slow down Wegovy results:

Starting dose and dose increases

Wegovy is intentionally started at a low dose and increased slowly to minimise side effects.

Treatment usually begins at 0.25mg once weekly, with the dose increased every four weeks until you reach a maintenance dose.

Because of this gradual ramp-up, it can take time for the medication to reach its full effect.

Most people don’t notice their most significant weight loss until they reach the higher doses, typically 1.7mg to 2.4mg, which is usually around months 3 to 5 of treatment.

Note: You do not need to progress to the highest Wegovy dose. Once you reach a dose that delivers steady weight loss with minimal side effects, you should remain on that dose.

Diet and physical activity

Wegovy works best when it’s paired with a broader lifestyle approach. While the medication helps reduce appetite and curb cravings, your daily habits still have a major influence on how quickly and effectively you lose weight.

Eating balanced, lower-calorie meals and keeping portion sizes consistent can speed up your progress. Focus on whole foods such as lean proteins, vegetables, fruits, and healthy fats, and limit processed or high-sugar options.

Regular physical activity also enhances results. You don’t need intense workouts, even a 30-minute daily walk or light strength training a few times a week can make a noticeable difference in how your body responds to Wegovy.

The more consistent you are with healthy habits, the sooner you’re likely to see meaningful, sustainable changes.

Metabolism and body type

Everyone responds to Wegovy at their own pace. Factors like metabolism, genetics, age, sex, and hormone levels all affect how quickly you lose weight.

People with a slower metabolism or hormonal conditions such as PCOS or thyroid issues may lose weight more gradually, even with the same routine. Age can also slow progress due to natural metabolic changes.

Body composition plays a part too. Those building more muscle may not necessarily see the scales move as much, compared to someone with a higher body fat composition.

Wegovy isn’t a one-size-fits-all treatment. Some see results quickly, others take longer, both are normal. The key is consistency and giving your body time to respond.

Other medical conditions or medications

Your overall health and any medications you take can influence how well and how quickly Wegovy works.

Conditions such as hypothyroidism, insulin resistance, PCOS, or Cushing’s syndrome can make weight loss more challenging because they affect how your body stores fat, burns calories, and regulates appetite.

Certain medications including insulin, beta-blockers, some antidepressants, and steroids, can also slow progress or contribute to weight gain. This doesn’t mean Wegovy won’t work; it simply means results may be slower or require closer monitoring with your prescriber.

Consistency and adherence

Wegovy works best when taken consistently and exactly as prescribed. Skipping doses, taking them late, or pausing treatment can slow your progress and reduce its effectiveness.

Because Wegovy builds up gradually in your system, interruptions can disrupt this process and may lead to increased hunger, cravings, or stalled weight loss.

Key take aways

  • Wegovy begins reducing appetite in the first week, but visible weight loss usually starts around 1-2 months.
  • Noticeable results typically begin from the 0.5mg-1mg doses during months 2-3.
  • By 3 months, most people see clear, visible weight loss (around 6% of starting weight).
  • By 6 months, you should be on your way to losing 17% of your starting weight
  • How quickly Wegovy works depends on dose increases, lifestyle habits, metabolism, other health conditions, and how consistently you take it.

Frequently Asked Questions

Noticeable weight loss is unlikely in the first week of Wegovy, though you may see early signs of your appetite decreasing. Side effects such as nausea, diarrhoea, or constipation can occur in the first week.

Most people start to notice weight loss after 1 month of using Wegovy, especially as the dose increases. Visible changes, like how clothes fit, often show up before big drops on the scale.

Wegovy technically starts working from the very first dose (0.25mg), because this is when your body begins responding to Semaglutide. However, 0.25mg is a starter dose and is not strong enough for meaningful weight loss. It is mainly to let your body adjust.

You should start seeing noticeable weight loss with Wegovy at the 0.5mg dose, after the first month of treatment.

According to clinical trials, the expected weight loss on Wegovy is:

  • Month 1 – 2%
  • Month 2 – 4%
  • Month 3 – 6%
  • Month 4 – 8%
  • Month 5 – 10%
  • Month 6-17 – 17%

Most people take Wegovy long term for weight loss. Treatment usually continues for as long as you are benefiting, meaning you are losing weight or maintaining weight loss without problematic side effects.

In clinical trials, people lost up to 17% of their starting weight after 68 weeks of treatment.

Your doctor or pharmacist will review your progress regularly, but there is no fixed time limit; Wegovy is considered safe for extended use when monitored appropriately.


Whilst all of our content is written and reviewed by healthcare professionals, it is not intended to be substituted for or used as medical advice. If you have any questions or concerns about your health, please speak to your doctor.

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