What are the side effects of fexofenadine?

Fexofenadine hydrochloride tablets are generally well tolerated, but like all medicines, it can cause side effects in some people. The most commonly reported side effects include headache, feeling sleepy, nausea and dizziness.

Most side effects are mild and may improve as your body gets used to the medicine. However, you should speak to a pharmacist or doctor if side effects are severe, persistent or affecting your daily activities.

Common fexofenadine side effects

Common side effects are those that may affect more than 1 in 100 people.

Side effect What it may feel like What you can do
Headache Mild to moderate head pain Drink plenty of water and rest. Speak to a pharmacist if it continues.
Feeling sleepy Tiredness, reduced alertness or drowsiness Avoid driving or using machinery until you know how fexofenadine affects you.
Feeling sick Nausea or unsettled stomach Stick to simple meals and avoid rich or spicy food.
Dizziness Feeling light-headed or unsteady Sit or lie down until it passes. Avoid driving if affected.

 

Although fexofenadine is described as a non-drowsy antihistamine, it can still cause sleepiness in some people.

Serious fexofenadine side effects

Serious side effects are uncommon, but they can happen.

Seek urgent medical help if you develop symptoms of a serious allergic reaction, such as:

  • swelling of the face, lips, tongue or throat
  • difficulty breathing
  • tightness in the chest
  • severe skin rash
  • fainting or feeling like you may collapse

These symptoms could suggest a serious allergic reaction and should be treated as a medical emergency.

Does fexofenadine make you sleepy?

Fexofenadine is classed as a non-drowsy antihistamine. This means it is less likely to cause sleepiness than older antihistamines, such as chlorphenamine or promethazine.

However, some people still feel sleepy or less alert after taking fexofenadine. If this happens, do not drive, cycle or operate machinery until you feel fully awake and alert.

If sleepiness continues, speak to a pharmacist or doctor. Another antihistamine may be more suitable.

Can fexofenadine cause headaches?

Yes. Headache is one of the most commonly reported side effects of fexofenadine.

A mild headache may improve with rest, fluids and time. If the headache is severe, persistent or unusual for you, speak to a healthcare professional.

You should also check whether dehydration, poor sleep, alcohol, other medicines or your allergy symptoms could be contributing to the headache.

Can fexofenadine cause dizziness?

Yes. Some people may feel dizzy after taking fexofenadine.

If you feel dizzy, sit or lie down until it passes. Avoid alcohol and avoid driving or using machinery if you feel light-headed or unsteady.

If dizziness continues or feels severe, speak to a pharmacist or doctor.

In most cases, the side effects associated with taking fexofenadine are mild, and will not require medical attention. However, if your side effects do not go away, or they appear to be serious, including but not limited to trouble breathing, swelling of the face, throat, or lips, you should seek emergency medical help. These are signs of an allergic reaction.

Can fexofenadine cause nausea?

Yes. Feeling sick or nauseous can happen with fexofenadine.

Taking fexofenadine before food with water may help. Avoid rich, greasy or spicy meals if nausea occurs.

If nausea is severe, persistent or associated with vomiting, abdominal pain or dehydration, seek medical advice.

Fexofenadine 180mg side effects

Fexofenadine 180mg can cause similar side effects to other strengths of fexofenadine. These may include headache, drowsiness, nausea and dizziness.

The 180mg strength is a higher dose and is commonly used for hives and persistent allergy symptoms. Do not take more than the recommended dose of fexofenadine unless advised by a healthcare professional.

 

Side effect What it may feel like What you can do
Headache Mild to moderate head pain Drink plenty of water and rest. Speak to a pharmacist if it continues.
Feeling sleepy Tiredness, reduced alertness or drowsiness Avoid driving or using machinery until you know how fexofenadine affects you.
Feeling sick Nausea or unsettled stomach Stick to simple meals and avoid rich or spicy food.
Dizziness Feeling light-headed or unsteady Sit or lie down until it passes. Avoid driving if affected.

Fexofenadine 120mg side effects

Fexofenadine 120mg can also cause side effects, although many people take it without problems. The most common side effects are similar to the 180mg dose and include headache, drowsiness, nausea and dizziness.

Fexofenadine 120mg is commonly used for hay fever symptoms such as sneezing, runny nose, itchy eyes and itchy throat.

Can fexofenadine cause long-term side effects?

There is no strong evidence that fexofenadine commonly causes long-term side effects when taken as directed. Many people use it during allergy seasons or for ongoing allergy symptoms without major problems.

However, you should speak to a pharmacist or doctor if you need fexofenadine every day for a long time, your symptoms are not controlled, or you develop new or persistent side effects.

You should not keep increasing the dose without medical advice.

Can fexofenadine affect your heart?

Palpitations and a fast or irregular heartbeat have been reported with fexofenadine, but the frequency is not known.

If you notice chest pain, fainting, severe dizziness, a fast heartbeat or an irregular heartbeat after taking fexofenadine, seek medical advice urgently.

People with existing heart problems should check with a pharmacist or doctor before taking fexofenadine.

Can fexofenadine cause anxiety or sleep problems?

Sleep problems, nervousness, insomnia and bad dreams have been reported, but they are not among the most common side effects.

If you feel anxious, restless or unable to sleep after taking fexofenadine, try taking it earlier in the day and speak to a pharmacist if symptoms continue.

Can you drink alcohol with fexofenadine?

Alcohol is not usually listed as a direct interaction with fexofenadine, but it can make side effects such as dizziness, tiredness or drowsiness worse.

If fexofenadine makes you sleepy or light-headed, avoid alcohol.

Who is more likely to get side effects?

You may be more likely to experience side effects or need extra caution if you:

  • are older
  • have kidney or liver problems
  • have heart problems
  • are pregnant or breastfeeding
  • take other medicines
  • take more than the recommended dose
  • are sensitive to antihistamines

Always read the patient leaflet and ask a pharmacist if you are unsure whether fexofenadine is suitable for you.

When should you speak to a doctor or pharmacist?

Speak to a pharmacist or doctor if:

  • side effects do not go away
  • side effects are severe or affecting daily life
  • you feel very sleepy, dizzy or unwell
  • your allergy symptoms are not improving
  • you need fexofenadine every day for a long period
  • you have heart, kidney or liver problems
  • you are pregnant or breastfeeding

Seek urgent medical help if you develop breathing difficulty, swelling of the face or throat, chest pain, fainting or signs of a severe allergic reaction.

Final thoughts

Fexofenadine is a commonly used non-drowsy antihistamine and is generally well tolerated. The most common side effects are headache, feeling sleepy, nausea and dizziness.

Although serious side effects are rare, it is important to know when to seek help. If you develop swelling of the face, lips, tongue or throat, breathing difficulty, chest tightness or a severe rash, seek urgent medical attention.

If side effects are mild, they may improve with time. If they continue or affect your daily activities, speak to a pharmacist or doctor.

Fexofenadine stays in your system for up to 12 hours after you take it; however, this can vary based on individual factors such as age, body weight, metabolism, and the dose.

Taking fexofenadine at a higher dose than what is recommended, or certain medical conditions such as kidney disease, can slow the breakdown process, reducing its elimination from your body. This can increase the chances of experiencing unwanted effects. Always stick to the recommended dose and do not double dose, even if you have forgotten to take your previous tablet.

Fexofenadine 180mg can cause the same types of side effects as other strengths, including headache, drowsiness, nausea and dizziness. Do not take more than the recommended dose unless advised by a healthcare professional.


  1. NHS. Side effects of fexofenadine. https://www.nhs.uk/medicines/fexofenadine/side-effects-of-fexofenadine/

  2. NHS. About fexofenadine. https://www.nhs.uk/medicines/fexofenadine/about-fexofenadine/

  3. electronic Medicines Compendium. Fexofenadine hydrochloride 180mg film-coated Tablets: Patient Information Leaflet. https://www.medicines.org.uk/emc/product/3488/pil

  4. NICE BNF. Fexofenadine hydrochloride. https://bnf.nice.org.uk/drugs/fexofenadine-hydrochloride/

Whilst all of our content is written and reviewed by healthcare professionals, it is not intended to be substituted for or used as medical advice. If you have any questions or concerns about your health, please speak to your doctor.

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