for illustration purposes

Epiduo Gel

From £30.85 See Prices

Epiduo gel is an acne treatment which contains benzoyl peroxide and adapalene. Benzoyl peroxide works by getting rid of dead skin cells, excess oil and bacteria from under the skin. Adapalene renews skin cells and has an anti-inflammatory effect, reducing swelling and redness.

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From £30.85
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Medicine x1 Pump (45g) x2 Pumps (90g)
Epiduo 0.1%/2.5% Pump £30.85 £59.99
Epiduo 0.3%/2.5% Pump £33.95 £65.45

About Epiduo

Key points

  • Promotes skin renewal
  • Reduces the build up of bacteria on the skin
  • Clears acne, prevents breakouts and restores skin tone and texture


Buy Epiduo gel online

You can buy Epiduo online from Chemist Click, with next day delivery options available. Epiduo is not available to buy over the counter, so you will need to complete a short online questionnaire, for our pharmacists to assess beforehand.

What is Epiduo?

Epiduo is a topical acne treatment which contains adapalene (a retinoid) and benzoyl peroxide. Both ingredients work together to unblock pores and kill bacteria on the skin.

How long does Epiduo take to work?

It can take around 2-4 weeks before you start to notice a difference.

How to use Epiduo

Wash your hands and the affected area with a gentle cleanser

  1. Make sure the area is dry
  2. Apply a thin layer of gel onto the affected area, once at night


Important note: Do not apply Epiduo near the eyes, on broken skin, or on sensitive areas of the skin

What happens when you stop using Epiduo?

Acne may return, especially if it has not fully cleared. You can continue using Epiduo even after acne has cleared, to help prevent outbreaks of acne.

Epiduo before and after results

Epiduo results are usually visible after 4 weeks. It is a good idea to take pictures of the affected area, so that you can assess the results on a weekly basis.

To find out more, visit our Epiduo reviews page.

Epiduo side effects

Side effects of Epiduo include:

Common (affecting up to 10% of people)

  • Skin irritation
  • Eczema
  • Burning sensation on the skin


Uncommon (affecting up to 1% of people)

  • Eyelid irritation
  • Tingling at the site of application
  • Itchy skin
  • Skin reactions
  • Dry skin
  • Rash


Epiduo purging

Skin purging happens when your skin is getting rid of unwanted substances which cause acne. These substances are pushed to the surface of your skin, before being eliminated. This can make your acne worse, before it gets better. Epiduo can cause skin purging within the first couple of weeks. It usually lasts for 2 weeks. It is important to continue to use Epiduo, even if you are experiencing skin purging.

For more information, visit our page ‘What is skin purging?’.

Epiduo warnings

Avoid using Epiduo:

  • If you have eczema, cuts, sunburn or grazes at the site of application
  • If you are exposed to areas of extreme sunlight or ultraviolet light
  • Around your eyes, nostrils, mouth, or sensitive areas of your body
  • If you are allergic to any of the ingredients in Epiduo

Epiduo and pregnancy

Do not use Epiduo if you are pregnant or planning to become pregnant.

Epiduo and breastfeeding

Epiduo is safe to use if you are breastfeeding.

Epiduo alternatives

Epiduo vs Duac

  • Duac and Epiduo both contain benzoyl peroxide.
  • Duac contains an antibiotic, clindamycin
  • Epiduo contains a retinoid, adapalene
  • It is common practice to treat acne using Epiduo first, before using Duac
  • You cannot become resistant to Differin, as it does not contain an antibiotic. This means that you can use treatment over a longer period of time, to help prevent acne, as well as treating it
  • You should stop using Duac after 12 weeks, to avoid your skin becoming resistant to it


Epiduo vs Differin

  • Epiduo and Differin both contain adapalene
  • The only difference is that Epiduo contains benzoyl peroxide
  • For those that find Epiduo to be effective but irritating to the skin, Differin may prove to be gentler, as it does not contain benzoyl peroxide
  • Those that experience mild relief with Differin, may experience better results with Epiduo


Epiduo vs Epiduo Forte

  • Both Epiduo and Epiduo Forte contain adapalene and benzoyl peroxide
  • Epiduo contains 0.1%, whilst Epiduo Forte contains 0.3% adapalene
  • In theory, Epiduo Forte is stronger than Epiduo

Epiduo Ingredients

Active ingredient: Adapalene 0.1% (Epiduo) or Adapalene 0.3% (Epiduo Forte), benzoyl peroxide 2.5%

Inactive ingredients: Glycerol, disodium edetate, docusate sodium, poloxamer, Simulgel 600 PHA (copolymer of acrylamide and sodium acryloyldimethyltaurate, isohexadecane, sorbitan oleate, polysorbate 80) and purified water


Galderma Laboratories (n.d.) Epiduo Patient Information Leaflet. Available at: (Accessed: 04 March 2024).

No, Epiduo is a retinoid. Both are derivatives of vitamin A, but retinoids are stronger.

Epiduo Forte contains 0.3% adapalene, and Epiduo gel contains 0.1% adapalene. Both Epiduo and Epiduo forte contain 2.5% benzoyl peroxide.

Skin burning is a common side effect of Epiduo, which usually subsides within the first few weeks of treatment. If burning is intense and shows no signs of calming down, stop using Epiduo and speak to your doctor.

This is known as skin purging and is common within the first few weeks of treatment. Continue to use Epiduo and night, and a gentle moisturiser during the day.

Yes, Epiduo can help to rejuvenate skin, as it promotes the turnover of skin cells.

Yes, wait a few minutes for Epiduo to dry before applying moisturiser.

Yes, Epiduo is safe to use every day.

Yes, you can use Epiduo whilst wearing make-up. But be sure to use non-comedogenic and oil free products. Nevertheless, Epiduo gel should be applied in the evening before bed therefore you probably won’t be applying both at the same time. If for some reason, you need to apply make-up, wait for the gel to dry before applying any products.

No, In the UK, Epiduo is a prescription acne cream which must be approved by a medical professional first. It is recommended that you speak to your doctor before trying any acne medication.

You can buy Epiduo online through our website once you have completed a short consultation. Once the consultation has been approved by one of our doctors, we will swiftly send the prescription to you in a discreet package. 

Epiduo is available on the NHS, however, this will be at the discretion of your doctor.

Product Reviews For Epiduo Gel

Epiduo is undoubtedly an effective acne treatment used to eliminate harmful bacteria on the skin, reduce redness and inflammations and get rid of whiteheads and blackheads. Even though we’ve talked about this throughout, it’s important you get an unbiased view of what the product is really like from the people that matter, the reviewers.


  • There seems to be a general consensus that Epiduo is very effective at clearing up spots
  • Most reviewers explain that the product is easy to use and suitable for persistent teenage and adult acne
  • Some patients have described the product as ‘miracle cream’
  • Minimises dry and flakey skin
  • Customers have commented that they begin to see results within weeks
  • Minimal side effects
  • Comes in gel form which means it doesn’t require oral medication


  • Epiduo purge
  • Do not apply to a sunburnt areas as it can give you blisters
  • Not recommended to use if you’re pregnant or breastfeeding


Whilst some customers experienced some minor side effects, (you can find out more about Epiduo side effects in the "About" section), the positives definitely outweigh the negatives. Especially since the majority of patients did not experience any adverse effects. we’re confident in recommending this treatment to teens and adults suffering from mild to moderate acne.

Summary For Epiduo Gel

Medication class Retinoid
Mechanism of action Promotes skin renewal and unclogs pores
Active ingredient Adapalene & benzoyl peroxide

0.1%/2.5% (Epiduo)
0.3%/2.5% (Epiduo Forte)

Effective within 2 weeks
Dosage instructions Apply a thin layer at night, to the affected area(s)
Manufacturer Galderma
Use with alcohol n/a

See over 19 product reviews

Product rated 5/5

Epiduo Gel
Best gel for acne

By Iwona Roman, 07th of March

Epiduo Gel
Seems to be doing what people say it should be.

By Indie Alexandrou, 27th of January

Epiduo Gel
Strong but works, go light

By Misbah Batool, 24th of October

Epiduo Gel
The best gel for acne

By Iwona Roman, 08th of September

Epiduo Gel
Top class in general...

By Abdirahman Hoosh, 22nd of July

See More Reviews


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