Buy Epiduo gel online

You can buy Epiduo online from Chemist Click, with next day delivery options available. Epiduo is not available to buy over the counter, so you will need to complete a short online questionnaire, for our pharmacists to assess beforehand.

Epiduo Gel Prices

Name & Dosage x1 Pump
(45g)
x1 Pump
(60g)
x2 Pumps
(90g)
x2 Pumps
(120g)
Epiduo 0.1%/2.5% Pump
(45g)
£30.85
Epiduo 0.1%/2.5% Pumps
(90g)
£59.99
Epiduo 0.1%/2.5% Pump
(60g)
£37.80
Epiduo 0.1%/2.5% Pumps
(120g)
£73.60
Epiduo 0.3%/2.5% Pump
(45g)
£33.95
Epiduo 0.3%/2.5% Pumps
(90g)
£65.45
Epiduo 0.3%/2.5% Pump
(60g)
£40.80
Epiduo 0.3%/2.5% Pumps
(120g)
£79.60

Summary for Epiduo Gel

Medication class Retinoid
Mechanism of action Promotes skin renewal and unclogs pores
Active ingredient Adapalene & benzoyl peroxide
Strength 0.1%/2.5% (Epiduo)
0.3%/2.5% (Epiduo Forte)
Effective within Early improvement usually seen within 1 to 4 weeks
Dosage instructions Apply a thin layer at night, to the affected area(s)
Manufacturer Galderma
Use with alcohol N/A

Key points

  • Promotes skin renewal
  • Reduces the build up of bacteria on the skin
  • Clears acne, prevents breakouts and restores skin tone and texture

What is Epiduo?

Epiduo is a topical acne treatment which contains adapalene (a retinoid) and benzoyl peroxide. Both ingredients work together to unblock pores and kill bacteria on the skin.

How long does Epiduo take to work?

It can take around 1-4 weeks before you start to notice a difference.

How to use Epiduo

Wash your hands and the affected area with a gentle cleanser

  1. Make sure the area is dry
  2. Apply a thin layer of gel onto the affected area, once at night

Important note: Do not apply Epiduo near the eyes, on broken skin, or on sensitive areas of the skin.

What happens when you stop using Epiduo?

Acne may return, especially if it has not fully cleared. You can continue using Epiduo even after acne has cleared, to help prevent outbreaks of acne.

Epiduo before and after results

Epiduo results are usually visible after 4 weeks. It is a good idea to take pictures of the affected area, so that you can assess the results on a weekly basis.

To find out more, visit our Epiduo reviews page.

Epiduo purging

Skin purging happens when your skin is getting rid of unwanted substances which cause acne. These substances are pushed to the surface of your skin, before being eliminated. This can make your acne worse, before it gets better.

When you start Epiduo, your skin may become dry, red, flaky or irritated. This is common and usually settles within the first few weeks as your skin adjusts. If irritation is severe or does not improve, reduce how often you apply it or stop, and speak to your prescriber.

For more information, visit our page ‘What is skin purging?’.

Epiduo alternatives

Epiduo vs Duac

  • Duac and Epiduo both contain benzoyl peroxide.
  • Duac contains an antibiotic, clindamycin
  • Epiduo contains a retinoid, adapalene
  • Epiduo and Duac are both recommended first-line treatments for mild to moderate acne in NICE guidance. They work in different ways: Epiduo combines a retinoid-like ingredient with benzoyl peroxide, while Duac combines an antibiotic with benzoyl peroxide. Our prescriber will recommend the most suitable option based on your acne type, skin sensitivity and treatment history.
  • You should stop using Duac after 12 weeks, to reduce the risk of antibiotic resistance

Epiduo vs Differin

  • Epiduo and Differin both contain adapalene
  • The only difference is that Epiduo contains benzoyl peroxide
  • For those that find Epiduo to be effective but irritating to the skin, Differin may prove to be gentler, as it does not contain benzoyl peroxide
  • Those that experience mild relief with Differin, may experience better results with Epiduo

Epiduo vs Epiduo Forte

  • Both Epiduo and Epiduo Forte contain adapalene and benzoyl peroxide
  • Epiduo contains 0.1%, whilst Epiduo Forte contains 0.3% adapalene
  • In theory, Epiduo Forte is stronger than Epiduo

Epiduo Ingredients

Active ingredient: Adapalene 0.1% (Epiduo) or Adapalene 0.3% (Epiduo Forte), benzoyl peroxide 2.5%

Inactive ingredients: Glycerol, disodium edetate, docusate sodium, poloxamer, Simulgel 600 PHA (copolymer of acrylamide and sodium acryloyldimethyltaurate, isohexadecane, sorbitan oleate, polysorbate 80) and purified water

Epiduo Gel Dosage Instructions

Apply a thin layer at night, to the affected areas.

Epiduo Side Effects

Like all medicines, Epiduo can cause side effects, although not everybody gets them. Most are mild and affect the treated skin, usually in the first few weeks.

Common (may affect up to 1 in 10 people): dry skin, redness, skin peeling, burning sensation, skin irritation and local skin rash (irritant contact dermatitis).

Uncommon (may affect up to 1 in 100 people): itching and sunburn.

Stop using Epiduo and get urgent medical help if you notice swelling of the face, eyelids or lips, tightness in the throat or difficulty breathing. These can be signs of an allergic reaction.

Epiduo Gel Warnings

Avoid using Epiduo:

  • If you have eczema, cuts, sunburn or grazes at the site of application
  • If you are exposed to areas of extreme sunlight or ultraviolet light
  • Around your eyes, nostrils, mouth, or sensitive areas of your body
  • If you are allergic to any of the ingredients in Epiduo

Epiduo Gel and Pregnancy/Breastfeeding

Do not use Epiduo if you are pregnant or planning to become pregnant.

Epiduo can be used while breastfeeding, as very little is absorbed into the body. Do not apply it to the chest area, to avoid your baby coming into contact with the gel. Tell our prescriber if you are breastfeeding.

Frequently Asked Questions

No, Epiduo is a retinoid. Both are derivatives of vitamin A, but retinoids are stronger.

Epiduo Forte contains 0.3% adapalene, and Epiduo gel contains 0.1% adapalene. Both Epiduo and Epiduo forte contain 2.5% benzoyl peroxide.

Skin burning is a common side effect of Epiduo, which usually subsides within the first few weeks of treatment. If burning is intense and shows no signs of calming down, stop using Epiduo and speak to your doctor.

This is known as skin purging and is common within the first few weeks of treatment. Continue to use Epiduo at night, and a gentle moisturiser during the day.

Yes, wait a few minutes for Epiduo to dry before applying moisturiser.

Yes, Epiduo is safe to use every day.

Yes, you can use Epiduo whilst wearing make-up. But be sure to use non-comedogenic and oil free products. Nevertheless, Epiduo gel should be applied in the evening before bed therefore you probably won’t be applying both at the same time. If for some reason, you need to apply make-up, wait for the gel to dry before applying any products.

No, In the UK, Epiduo is a prescription acne cream which must be approved by a medical professional first. It is recommended that you speak to your doctor before trying any acne medication.

You can buy Epiduo online through our website once you have completed a short consultation. Once the consultation has been approved by one of our doctors, we will swiftly send the prescription to you in a discreet package.

Epiduo is available on the NHS, however, this will be at the discretion of your doctor.

Written and clinically reviewed by our pharmacists

Abbas Kanani, MRPharmS
Written by

Abbas Kanani,
MRPharmS

View profile →
✓ Founder & Superintendent Pharmacist
✓ GPhC no. 2082291
✓ 13+ years experience
Clinically reviewed by

Hadi Habboushi,
MPharm

View profile →
✓ Independent Prescriber
✓ GPhC no. 2229049
✓ 5+ years experience
How we ensure accuracy →
First created 22nd April 2025
Last clinically reviewed 27th October 2026
Next review 27th October 2027

Epiduo Gel Reviews

Product rated 4.9/5

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"Janelle's Review"

This is the best product i have used for acne and acne scars so far, no other product has helped or done what this does. Highly recommend. I have had acne for years and had tried numerous products as well as going to professionals. I have even had microneedling and chemical peels. nothing had worked so far but this product works. Just be careful because when you start it’s a harsh product you will experience peeling and it might feel like it’s burning but try it.

By Janelle
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"Iwona's Review"

For acne the best

By Iwona Roman
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"Iwona's Review"

Best gel for acne

By Iwona Roman
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"Indie's Review"

Seems to be doing what people say it should be.

By Indie Alexandrou

Customer reviews reflect individual experiences and are not medical advice.

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