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Epiduo Gel 45g/60g/90g/120g
from
£30.85
Epiduo gel is an acne treatment which contains benzoyl peroxide and adapalene. Benzoyl peroxide works by getting rid of dead skin cells, excess oil and bacteria from under the skin. Adapalene renews skin cells and has an anti-inflammatory effect, reducing swelling and redness.
Epiduo Gel 45g/60g/90g/120g
Buy Epiduo gel online
You can buy Epiduo online from Chemist Click, with next day delivery options available. Epiduo is not available to buy over the counter, so you will need to complete a short online questionnaire, for our pharmacists to assess beforehand.
Epiduo Gel Prices
| Name & Dosage | x1 Pump (45g) |
x1 Pump (60g) |
x2 Pumps (90g) |
x2 Pumps (120g) |
|---|---|---|---|---|
| Epiduo 0.1%/2.5% Pump (45g) |
£30.85 | |||
| Epiduo 0.1%/2.5% Pumps (90g) |
£59.99 | |||
| Epiduo 0.1%/2.5% Pump (60g) |
£37.80 | |||
| Epiduo 0.1%/2.5% Pumps (120g) |
£73.60 | |||
| Epiduo 0.3%/2.5% Pump (45g) |
£33.95 | |||
| Epiduo 0.3%/2.5% Pumps (90g) |
£65.45 | |||
| Epiduo 0.3%/2.5% Pump (60g) |
£40.80 | |||
| Epiduo 0.3%/2.5% Pumps (120g) |
£79.60 | |||
Summary for Epiduo Gel
| Medication class | Retinoid |
|---|---|
| Mechanism of action | Promotes skin renewal and unclogs pores |
| Active ingredient | Adapalene & benzoyl peroxide |
| Strength | 0.1%/2.5% (Epiduo) 0.3%/2.5% (Epiduo Forte) |
| Effective within | 2 weeks |
| Dosage instructions | Apply a thin layer at night, to the affected area(s) |
| Manufacturer | Galderma |
| Use with alcohol | N/A |
About Epiduo
Key points
- Promotes skin renewal
- Reduces the build up of bacteria on the skin
- Clears acne, prevents breakouts and restores skin tone and texture
What is Epiduo?
Epiduo is a topical acne treatment which contains adapalene (a retinoid) and benzoyl peroxide. Both ingredients work together to unblock pores and kill bacteria on the skin.
How long does Epiduo take to work?
It can take around 2-4 weeks before you start to notice a difference.
How to use Epiduo
Wash your hands and the affected area with a gentle cleanser
- Make sure the area is dry
- Apply a thin layer of gel onto the affected area, once at night
Important note: Do not apply Epiduo near the eyes, on broken skin, or on sensitive areas of the skin.
What happens when you stop using Epiduo?
Acne may return, especially if it has not fully cleared. You can continue using Epiduo even after acne has cleared, to help prevent outbreaks of acne.
Epiduo before and after results
Epiduo results are usually visible after 4 weeks. It is a good idea to take pictures of the affected area, so that you can assess the results on a weekly basis.
To find out more, visit our Epiduo reviews page.
Epiduo purging
Skin purging happens when your skin is getting rid of unwanted substances which cause acne. These substances are pushed to the surface of your skin, before being eliminated. This can make your acne worse, before it gets better. Epiduo can cause skin purging within the first couple of weeks. It usually lasts for 2 weeks. It is important to continue to use Epiduo, even if you are experiencing skin purging.
For more information, visit our page ‘What is skin purging?’.
Epiduo alternatives
Epiduo vs Duac
- Duac and Epiduo both contain benzoyl peroxide.
- Duac contains an antibiotic, clindamycin
- Epiduo contains a retinoid, adapalene
- It is common practice to treat acne using Epiduo first, before using Duac
- You cannot become resistant to Differin, as it does not contain an antibiotic. This means that you can use treatment over a longer period of time, to help prevent acne, as well as treating it
- You should stop using Duac after 12 weeks, to avoid your skin becoming resistant to it
Epiduo vs Differin
- Epiduo and Differin both contain adapalene
- The only difference is that Epiduo contains benzoyl peroxide
- For those that find Epiduo to be effective but irritating to the skin, Differin may prove to be gentler, as it does not contain benzoyl peroxide
- Those that experience mild relief with Differin, may experience better results with Epiduo
Epiduo vs Epiduo Forte
- Both Epiduo and Epiduo Forte contain adapalene and benzoyl peroxide
- Epiduo contains 0.1%, whilst Epiduo Forte contains 0.3% adapalene
- In theory, Epiduo Forte is stronger than Epiduo
Epiduo Ingredients
Active ingredient: Adapalene 0.1% (Epiduo) or Adapalene 0.3% (Epiduo Forte), benzoyl peroxide 2.5%
Inactive ingredients: Glycerol, disodium edetate, docusate sodium, poloxamer, Simulgel 600 PHA (copolymer of acrylamide and sodium acryloyldimethyltaurate, isohexadecane, sorbitan oleate, polysorbate 80) and purified water
Epiduo Gel Dosage Instructions
Apply a thin layer at night, to the affected areas.
Epiduo Side Effects
Side effects of Epiduo include:
Common (affecting up to 10% of people)
- Skin irritation
- Eczema
- Burning sensation on the skin
Uncommon (affecting up to 1% of people)
- Eyelid irritation
- Tingling at the site of application
- Itchy skin
- Skin reactions
- Dry skin
- Rash
Epiduo Gel Warnings
Avoid using Epiduo:
- If you have eczema, cuts, sunburn or grazes at the site of application
- If you are exposed to areas of extreme sunlight or ultraviolet light
- Around your eyes, nostrils, mouth, or sensitive areas of your body
- If you are allergic to any of the ingredients in Epiduo
Epiduo Gel and Pregnancy/Breastfeeding
Do not use Epiduo if you are pregnant or planning to become pregnant.
Epiduo is safe to use if you are breastfeeding.
Frequently Asked Questions
No, Epiduo is a retinoid. Both are derivatives of vitamin A, but retinoids are stronger.
Epiduo Forte contains 0.3% adapalene, and Epiduo gel contains 0.1% adapalene. Both Epiduo and Epiduo forte contain 2.5% benzoyl peroxide.
Skin burning is a common side effect of Epiduo, which usually subsides within the first few weeks of treatment. If burning is intense and shows no signs of calming down, stop using Epiduo and speak to your doctor.
This is known as skin purging and is common within the first few weeks of treatment. Continue to use Epiduo at night, and a gentle moisturiser during the day.
Yes, Epiduo can help to rejuvenate skin, as it promotes the turnover of skin cells.
Yes, wait a few minutes for Epiduo to dry before applying moisturiser.
Yes, Epiduo is safe to use every day.
Yes, you can use Epiduo whilst wearing make-up. But be sure to use non-comedogenic and oil free products. Nevertheless, Epiduo gel should be applied in the evening before bed therefore you probably won’t be applying both at the same time. If for some reason, you need to apply make-up, wait for the gel to dry before applying any products.
No, In the UK, Epiduo is a prescription acne cream which must be approved by a medical professional first. It is recommended that you speak to your doctor before trying any acne medication.
You can buy Epiduo online through our website once you have completed a short consultation. Once the consultation has been approved by one of our doctors, we will swiftly send the prescription to you in a discreet package.
Epiduo is available on the NHS, however, this will be at the discretion of your doctor.
Product Reviews
product rated 4.9/5
This is the best product i have used for acne and acne scars so far, no other product has helped or done what this does. Highly recommend. I have had acne for years and had tried numerous products as well as going to professionals. I have even had microneedling and chemical peels. nothing had worked so far but this product works. Just be careful because when you start it’s a harsh product you will experience peeling and it might feel like it’s burning but try it.
By Janelle (via TrustPilot)
For acne the best
By Iwona Roman (via TrustPilot)
Best gel for acne
By Iwona Roman (via TrustPilot)
Seems to be doing what people say it should be.
By Indie Alexandrou (via TrustPilot)
Superintendent Pharmacist
Written by Chemist Click
First created 22nd April 2025
Last reviewed 1st October 2025
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