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Spedra Tablets

From £16.45 See Prices

Spedra tablets treat erectile dysfunction, taking effect in as little as 15 minutes. It can last for up to 4 hours. Spedra contains the active ingredient avanafil, which belongs to the class of medication called PDE5 inhibitors.

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Medicine x4 Tablets x8 Tablets x12 Tablets x16 Tablets x24 Tablets x32 Tablets
Spedra 50mg Tablets £16.45 £27.99 £43.99 £49.49 £77.45 £97.95
Spedra 100mg Tablets £19.45 £36.99 £55.99 £67.99 £104.95 £135.95
Spedra 200mg Tablets £29.45 £54.45 £82.95 £97.99 £149.95 £198.89

About Spedra

Key points

  • Fast acting taking 15 minutes to work
  • Lasts up to 4 hours
  • Works in 60-70% of men


Buy Spedra online

After completing an online consultation, You can buy Spedra online from our UK based pharmacy. Our parcels are dispatched in plain and discreet packaging, with next-day delivery options.

What is Spedra?

Spedra is a medication used to treat erectile dysfunction in men. It contains the active ingredient Avanafil, which belongs to the same class of drugs as Viagra (Sildenafil), Cialis (Tadalafil) and Levitra (Vardenafil). They are known as PDE-5 inhibitors.

How does Spedra work?

Spedra works by helping blood vessels in the penis to relax. This improves blood flow to the penis, allowing an erection to be achieved and maintained, upon sexual arousal.

Spedra will only work if you are sexually stimulated.

How long does Spedra take to work?

Spedra is fast acting and can take effect in as little as 15 minutes if taken on an empty stomach. Food reduces the absorption of Spedra it is best taken on an empty stomach, or at least 2 hours after food. Its average time to action when taken in optimal conditions, is around 15-30 minutes, however, this can vary upon the individual. It is the fastest acting ED tablet available.

How long does Spedra last?

Spedra lasts for up to 4 hours.

Spedra dosage instructions

How to take Spedra tablets

Take one tablet around 15 minutes before sexual activity.

Tablets should be taken on an empty stomach. Avoid alcohol.

Spedra 100mg

This is the recommended starting dose. Dose adjustments may be required depending on the response to treatment.

Spedra 50mg

This is the dose that is recommended if you have success with Spedra 100mg, but experience side effects.

Spedra 200mg

This dose will be recommended if you have limited success with Spedra 100mg. The higher the dose, the higher the chances of success. This however, comes with an increased risk of experiencing side effects.

Spedra ingredients

Active ingredient: Avanafil

Inactive ingredients: Fumaric acid, mannitol, magnesium stearate, hydroxypropyl cellulose, calcium carbonate and ferric oxide yellow (E172).

Spedra side effects

Like all medication, Spedra can cause side effects.

Side effects of Spedra include:

Common – affecting up to 10% of users:

  • Headache
  • Nasal congestion
  • Facial flushing


Uncommon – affecting up to 1% of users:

  • Dizziness
  • Fatigue
  • Back ache
  • Breathlessness when exercising
  • Blurred vision
  • Vomiting
  • Nausea
  • Stomach ache


Rare – affecting up to 0.1% of users:

  • Diarrhoea
  • Dry mouth
  • High blood pressure
  • Increased urination
  • Insomnia
  • Nosebleed
  • Blood in urine


If you experience any of the following symptoms, seek urgent medication attention:

  • An erection lasting for longer than 4 hours
  • Blurred vision or a sudden loss of vision
  • Decrease or loss of hearing
  • Chest pain
  • Signs of an allergic reaction such as difficulty breathing, swelling of the nose, eyes, mouth, throat


You should read the patient information leaflet for a full list of side effects and report any side effects to your doctor or pharmacist.

Spedra warnings

Do not take Spedra if you have:

  • Angina or other serious heart conditions
  • Had a stroke or heart attack within the last 6 months
  • Low blood pressure or uncontrolled high blood pressure
  • Serious liver or kidney problems
  • Altered vision due to lack of oxygen to the eye or certain eye conditions which are hereditary such as retinitis pigmentosa


You should inform your GP or pharmacist of any medication conditions you have, so that they can check if Spedra is safe for you to take.

Spedra interactions

Spedra can interact with certain medication such as:

  • Nitrates used to treat angina such as glyceryl trinitrate and isosorbide mononitrate
  • HIV and aids medication such as ritonavir, indinavir, saquinavir, nelfinavir, atazanavir
  • Antifungals such as ketoconazole, itraconazole
  • Antibiotics such as clarithromycin and erythromycin
  • Medication to reduce blood pressure in the lungs such as riociguat
  • Alpha-blockers used to treat high blood pressure and an enlarged prostate such as alfuzosin and tamsulosin
  • Anti-arrythmias used to treat irregular heartbeat such as quinidine, amiodarone and sotalol
  • Epilepsy medication such as phenobarbital carbamazepine


This is not a full list of interactions, and you should check with your doctor or pharmacist, whether Spedra can be taken with medication you currently take. It may still be possible to take Spedra, but dose adjustments are likely.

Spedra alternatives

Sildenafil – Takes 60 minutes to work and lasts for up to 4 hours. Also available as the branded version, Viagra.

Tadalafil – Takes 30 minutes to work and lasts for up to 36 hours. Also available as a daily tablet, which is taken every day providing a continuous window of action. Also available as the branded version, Cialis.

Vardenafil – Takes 25 minutes to work and lasts for up to 5 hours. Preferred option for diabetics.

Spedra vs Viagra

  • Spedra is faster acting working in 15 minutes, whilst Viagra takes 60 minutes to work
  • Both treatments last for up to 4 hours
  • Both treatments are affected by food
  • Viagra is more effective than Spedra, with a 90% success rate in comparison with Spedra’s 60-70% success rate
  • Spedra is not available as a generic brand, making it more expensive


Spedra vs Tadalafil

  • Spedra is faster acting taking 15 minutes to work, whilst tadalafil takes 30 minutes to work
  • Tadalafil is longer acting lasting for up to 36 hours, compared to Spedra which lasts for 4 hours
  • Tadalafil is not affected by food, whilst Spedra is
  • Tadalafil offers the advantage of a daily dosing tablet which has a continuous window of action. This benefits those who prefer a tablet which allows for spontaneous sex. Spedra does not offer this
  • Tadalafil has a success rate of 80-90% and Spedra has a success rate of 60-70%
  • Spedra is a branded drug, which is more expensive than tadalafil, which is a generic drug


  1. electronic Medicines Compendium. (n.d.). Vardenafil 5mg/10mg/20mg Film-coated Tablets - Summary of Product Characteristics (SmPC). Retrieved February 27, 2024, from

  2. NHS UK. (n.d.). Erection Problems (Erectile Dysfunction). Retrieved February 27, 2024, from

It is safe to drink moderate amounts of alcohol. Excess consumption can cause a drop in blood pressure. This will result in symptoms such as dizziness, light headedness and fainting.

You cannot take Spedra on the same day as other ED treatments.

It is safe to take Spedra every day. You should check this with you doctor or pharmacist beforehand.

During clinical trials, Spedra had a success rate of 58% in those that took the recommended starting dose of 100mg. The 200mg tablet was shown to be effective in 59% of subjects, whilst the 50mg tablet had a success rate of 47%. Although the success rate of Spedra is not as high as other ED treatments, it's targeted action mean that the chances of getting any side-effects are low. Spedra's quicker onset of action are appealing to many men, helping to achieve and maintain erections for spontaneous sexual encounters.

Product Reviews For Spedra Tablets

Summary For Spedra Tablets

Medication Class Phosphodiesterase 5 (PDE5) inhibitor
Mechanism of action Increases blood flow to the penis
Active ingredient Avanafil
Strength 50mg, 100mg, 200mg
Effective within 15 minutes
Dosage Instructions Take one tablet around 30 minutes before sexual activity
Manufacturer A. Menarini Farmaceutica Internazionale
Use with alcohol In moderation


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