Zomig Nasal Spray 5mg

A single dosage of Zomig is 5mg which is sprayed once in one nostril only. It doesn’t matter what nostril the medicine is sprayed into. If you still feel the migraine, you can use another spray after two hours, or if it returns within 24 hours.

• Do not use more than the dose prescribed for you
• Do not use more than two doses of spray in one day
• The maximum daily dose is 10 mg
• Do not take a double dose to make up for a forgotten dose
• You can use zomig spray with or without food

Seek urgent medical advice and tell your doctor if:

• You have used more Zomig nasal spray than prescribed

It’s best to use the spray as soon as a migraine headache starts. You can also use it once an attack is progressing.

Side effects are possible whilst using this medication. These tend to be mild and typically go away after a short time. Not every person will experience side effects.

Very common (1 in 10 people may be affected):  

• Taste disturbance

Common (up to 1 in 10 people may be affected):  

• Tingling in fingers and toes or skin that is sensitive to touch
• Feeling sleepy, warm or dizzy
• Headache
• Irregular heartbeat
• Nosebleed, irritation or the nose being extra sensitive
• Nausea or vomiting
• Stomach pain
• Dry mouth
• Muscle weakness or muscle pain
• Generally feeling weak
• Heaviness, tightness, pain or pressure in the throat, neck, arms and legs or chest
• Difficulty swallowing

Do not use Zomig Nasal Spray if:  

• You have zolmitriptan allergies or allergic to any other ingredients of this medicine
• You have high blood pressure
• You have experienced heart problems, including a heart attack, angina, Prinzmetal’s angina
• You have experienced heart-related symptoms such as shortness of breath or chest pressure
• You have had a stroke or short-lasting symptoms like stroke, such as transient ischaemic attack or TIA
• You are also taking other medicines for migraine, such as ergotamine or ergot-type medicines like dihydroergotamine and methysergide or other triptan medicines

Before using Zomig nasal spray you should talk to your doctor or pharmacist if any of the following apply to you:   

• You’re at risk of getting ischaemic heart disease (greater risk for smokers, people with high blood pressure or levels of cholesterol, diabetes or if anyone in your family has the disease
• You have been told that you have Wolff-Parkinson-White Syndrome
• You have ever had liver problems
• You have headaches, different to your usual migraine headache
• You take depression medicine

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, in particular:

• Migraine medicines
  • Wait 24 hours before using Zomig Nasal Spray if you use a triptan other than Zomig Nasal Spray (such as sumatriptan or naratriptan)
  • After using Zomig Nasal Spray leave 24 hours before taking another triptan.
  • Leave 24 hours before using Zomig if you take medicines containing ergotamine or ergot-type medicines (such as dihydroergotamine or methysergide)
  • After using Zomig leave 6 hours before taking ergotamine or ergot-type medicines
• Depression medicines
  • MAOIs such as moclobemide
  • SSRIs such as fluoxetine, paroxetine, fluvoxamine or sertraline
  • SNRIs such as venlafaxine or duloxetine
• Other medicines
  • Cimetidine for indigestion or stomach ulcers
  • A quinolone antibiotic such as ciprofloxacin

Serotonin syndrome is a rare, life-threatening condition that has been reported in some patients who took Zomig in combination with certain medicines for the treatment of depression.

Signs of serotonin syndrome include:

• Agitation or restlessness
• Fever or excessive sweating
• Tremor
• Uncoordinated movement of limbs or eyes
• Uncontrollable jerking of muscles
• Twitching and muscle rigidity

Do not take the herbal remedy St. John’s wort at the same time as Zomig Nasal Spray. If you already take a St. John’s wort preparation, stop and tell your doctor.

It is not known whether it is harmful to use Zomig Nasal Spray during pregnancy. You should seek medical advice if:

• You are pregnant
• You think you may be pregnant
• You are planning to have a baby

The same advice applies to those who are breastfeeding as to date, it is not known if Zomig Nasal Spray could affect breast milk. Speak to your doctor before taking this medication.

• NHS, 2024. Migraine: Treatment. [online] Available at: https://www.nhs.uk/conditions/migraine/treatment/ [Accessed 15 May 2024].