Foundayo Dosage Guide for Weight Loss

The Foundayo starting dose is 0.8mg once daily for at least 30 days.

This is the lowest available strength and is used to introduce the medicine gradually.

After at least 30 days, the licensed schedule says the dose should be increased to 2.5mg once daily.

Starting with a low dose helps the body adjust to Foundayo and is intended to reduce the likelihood and severity of gastrointestinal side effects.

These can include:

• nausea
• diarrhoea
• vomiting
• constipation
• indigestion
• abdominal discomfort

You should not start Foundayo at a higher dose unless specifically instructed to do so by your prescriber.

Further reading: Foundayo side effects

After taking Foundayo 0.8mg once daily for at least 30 days, the next dose is:

Foundayo 2.5mg once daily.

After at least another 30 days on 2.5mg, the dose may be increased to 5.5mg once daily.

From this point, further increases to 9mg, 14.5mg and 17.2mg are based on:

• how well Foundayo is working
• your appetite and weight response
• how well you tolerate the medicine
• whether you are experiencing side effects
• your prescriber’s clinical judgement

There is therefore no requirement for every patient to progress all the way to 17.2mg.

Foundayo does not have one single maintenance dose that is suitable for everyone.

Once you have progressed beyond the initial doses, your treatment can be adjusted according to how well it is working and how well you tolerate it.

Potential ongoing doses include:

• 5.5mg once daily
• 9mg once daily
• 14.5mg once daily
• 17.2mg once daily

You do not need to keep increasing the dose simply because a higher strength is available.

For example, if your current dose is producing a satisfactory response and you are tolerating it well, your prescriber may decide that there is no need to increase it immediately.

Equally, if the response is insufficient and the medicine is well tolerated, increasing to the next dose may be considered.

The highest dose of Foundayo is 17.2mg once daily.

In clinical trials, Foundayo 17.2mg helped people lose around 12.4% of their starting body weight over 72 weeks and 15% after 36 weeks.

Further reading: Orforglipron results

The dose of Foundayo is increased monthly. You will need to have taken it for at least 30 days, before increasing the dose.

Some people may need to stay on their current dose for longer to give their body more time to adjust before moving up. If you reach a dose that is helping to control your appetite and support weight loss, there may be no need to increase further. For many people, this is often seen from the 9mg dose onwards.

A simple way to think about it is:

Foundayo is started on a low introductory dose to help your body get used to the medicine and reduce the risk of side effects.

This first dose is not where the best weight loss results are usually seen. The stronger effects tend to come at the higher doses, which is why the dose is increased gradually over time.

Some people do notice good appetite suppression on lower doses and may choose to stay there, but overall, higher doses are more likely to produce greater weight loss.

Foundayo is increased gradually mainly to help improve tolerability.

GLP-1 receptor agonists commonly cause gastrointestinal side effects, particularly when treatment is first started or the dose is increased.

These can include:

• nausea
• diarrhoea
• vomiting
• constipation
• indigestion
• abdominal pain
• bloating

Moving through the doses gradually gives your body more time to adapt.

Increasing Foundayo faster than recommended does not necessarily mean you will lose weight faster and may increase the likelihood of side effects.

Further reading: Foundayo side effects

No. Not everyone taking Foundayo needs to reach 17.2mg.

The aim is not simply to reach the highest possible dose.

After the early stages of treatment, the dose is adjusted according to response and tolerability.

Some people may achieve an appropriate treatment response at a lower dose, while others may need to gradually move through the higher strengths.

The right dose is therefore individual rather than automatically being 17.2mg for everyone.

If you miss a dose of Foundayo, take it as soon as you remember. Do not take two doses together or double up your next dose.

If you have missed 7 or more days in a row, you may need to restart on a lower dose and increase gradually again to help reduce the risk of side effects. If this happens, speak to your prescriber or pharmacist for advice.

Foundayo’s dosing schedule is designed to help your body build up tolerance gradually, especially before moving to the higher doses, which are generally linked with greater average weight loss.

That does not mean everyone will need the highest dose. Some people may find that a lower dose is already helping to reduce appetite and support weight loss, and in those cases, it may be appropriate to stay there rather than keep increasing.

In practice, this should be an individualised decision made with your doctor or pharmacist, based on how well the medicine is working for you and how well you are tolerating it.