Yes. Wegovy tablets are licensed in the UK for weight management in eligible adults. They are taken once daily and contain oral semaglutide.

Other oral GLP-1 medicines are being studied, including orforglipron, but these are not currently licensed in the UK for weight loss.

You can buy GLP-1 tablets online from our UK registered pharmacy.

You will be required to complete a consultation online, which is checked by a pharmacist.

A supply will only be made if our prescribers deem you to be clinically suitable for a prescription.

GLP-1 tablets are medicines taken by mouth that act on the GLP-1 receptor. GLP-1 is a natural hormone involved in appetite, digestion and blood sugar control.

For weight management, GLP-1 medicines can help people feel fuller, reduce appetite and support weight loss when used alongside diet, physical activity and ongoing clinical support.

Not all GLP-1 medicines are tablets. Some GLP-1 medicines are injections, while others are tablets. The licensed use also depends on the exact medicine.

The main GLP-1 tablet for weight loss is Wegovy tablets, which contain semaglutide.

Wegovy tablets are different from Wegovy injections. Wegovy injections are taken once weekly, while Wegovy tablets are taken once daily. Both contain semaglutide, but they are not taken in the same way and should not be switched without clinical advice.

GLP-1 tablets work by acting on GLP-1 receptors in the body. This can affect appetite, fullness and how quickly the stomach empties.

For weight management, this may help people eat less and feel fuller for longer. GLP-1 tablets should be used alongside lifestyle changes, including a reduced-calorie diet and increased physical activity.

Clinical trials have shown that oral semaglutide can support weight loss in adults with overweight or obesity.

In the OASIS 4 phase 3 trial, oral semaglutide 25mg was studied in adults with overweight or obesity without type 2 diabetes. After 64 weeks, average body weight reduced by 13.6% with oral semaglutide 25mg, compared with 2.2% with placebo.

Among people who adhered to treatment, average weight loss was 16.6% with oral semaglutide 25 mg, compared with 2.7% with placebo.

Individual results vary. GLP-1 tablets are not a quick fix and work best as part of a structured weight-management plan.

Further reading: Wegovy tablet weight loss results

The instructions depend on the type of GLP-1 tablet. In the UK, Wegovy tablets are licensed for weight management, while orforglipron is still being studied in clinical trials and is not currently licensed.

Wegovy tablets are taken once daily on an empty stomach. They should be swallowed whole with a small amount of plain water after fasting for at least 8 hours. You should then wait at least 30 minutes before eating, drinking or taking other oral medicines.

Orforglipron is an investigational oral GLP-1 medicine. In clinical trials, it was studied as a once-daily tablet without the same food and water restrictions used for oral semaglutide. These were trial instructions only, not approved UK patient instructions.

For full instructions, read our detailed guide on how to take Wegovy tablets.

In the UK, Wegovy tablets are currently the main GLP-1 tablet licensed for weight management, so there is no direct licensed oral GLP-1 weight-loss tablet to compare it with. The best option depends on your BMI, medical history, side effects, preferences and prescriber assessment.

Wegovy tablets contain semaglutide and are taken once daily. Other oral GLP-1 medicines such as orforglipron are still being studied and should not be treated as available UK weight-loss treatments unless they become licensed.

Further reading: Wegovy tablets vs orforglipron

The most common side effects of GLP-1 tablets are usually:

• nausea
• vomiting
• diarrhoea
• constipation
• indigestion
• abdominal pain

These are usually most noticeable when starting treatment or increasing the dose.

In clinical trials, around 8% of people taking orforglipron stopped treatment due to side effects, compared with 6.8% for Wegovy tablets. In both cases, stomach-related side effects such as nausea, vomiting and diarrhoea were the main reason people stopped treatment.

For the right patient, prescribed through the correct route, GLP-1 tablets can be appropriate and effective treatments. However, they are still prescription medicines and are not suitable for everyone. Both Wegovy tablets and orforglipron carry warnings around important risks and require clinical screening before prescribing.

As with other GLP-1 medicines, they are generally not suitable for people with a personal or family history of medullary thyroid carcinoma or MEN2, and caution is needed in people with certain gastrointestinal issues, pancreatitis concerns, gallbladder disease, or other relevant medical conditions.

Prices start from £88.99 per month.

GLP-1 tablets are prescription-only medicines. In the UK, Wegovy tablets are licensed for weight management in eligible adults and should only be supplied after a clinical assessment by an appropriate healthcare professional.

You should only buy GLP-1 tablets from a registered UK pharmacy or regulated online clinic. A legitimate provider will check your BMI, medical history, current medicines and whether treatment is clinically suitable before prescribing.

Orforglipron is not currently licensed in the UK and should not be bought online or used outside an authorised clinical trial. Be cautious of websites claiming to sell cheap GLP-1 tablets, or offering them without a consultation or prescription, as these products may be unlicensed, counterfeit or unsafe.

Always check that an online pharmacy is registered with the General Pharmaceutical Council before ordering prescription weight-loss medication.

Further reading: How to buy orforglipron